圖源自網絡
你「最好看」的時候竟然是……凌晨四點
它跟你一樣：上班時間也愛摸魚
1、藍光：日光里的藍光照射會導致PER1不活躍，個人推測可能是藍光意味着blue，讓PER1的心情不好，主動下調錶達（並不是）；7
2、衰老：隨着年齡增長，角質形成細胞和成纖維細胞的MT-1受體表達減少，發給PER1的信號也就減少，social頻率的下降讓PER1深度emo，表達隨之減少；6
3、不良生活習慣：熬夜等打亂生物鐘的行為也可導致PER1下調，「覺都睡不夠還上什麼班！」，甚至當PER1不活躍時，身體還會反饋性地合成更多黑色素，以幫助PER1的表達水平回升。沒錯，這也是為什麼熬夜容易長斑的原因！8
PER1 開始007吧！
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10 Mahendra CK, Ser H-L, Pusparajah P, et al.Cosmeceutical Therapy: Engaging the Repercussions of UVR Photoaging on the Skin’s Circadian Rhythm. Int J Mol Sci2022; 23:2884.
11 Wang Q, Bozack SN, Yan Y, et al.Regulation of retinal inflammation by rhythmic expression of MiR-146a in diabetic retina. Invest Ophthalmol Vis Sci2014; 55:3986–94.
12 Xiao X, Xu M, Yu H, et al.Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src. Signal Transduct Target Ther2021; 6:354.
13 Dull K, Fazekas F, Deák D, et al.miR-146a modulates TLR1/2 and 4 induced inflammation and links it with proliferation and lipid production via the indirect regulation of GNG7 in human SZ95 sebocytes. Sci Rep2021; 11:21510.
14 Zhang L, Wang Q, Su H, Cheng J. Exosomes from Adipose Tissues Derived Mesenchymal Stem Cells Overexpressing MicroRNA-146a Alleviate Diabetic Osteoporosis in Rats. Cell Mol Bioeng2022; 15:87–97.
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